Cinco nuevos genes (MED23, FOXP1, MLLT4, XBP1 y ZFP36LT) y 13 tipos de mutaciones desconocidas hasta la fecha han sido descubiertas en el cáncer de mama. Es el último gran avance de una investigación oncológica realizada en el Wellcome Trust Sanger Institute (Reino Unido) y basada en la mayor secuenciación de genomas completos de personas con este tipo de tumor. En total, 560. Un descubrimiento que, según los investigadores, allana el camino en terapia personalizada.
Así se desprende de dos artículos que acaban de ver la luz en las revistas Nature y Nature Communications, en los que los autores exponen el análisis de los genomas de 556 mujeres y cuatro hombres con cáncer de mama, procedentes de Estados Unidos, Europa y Asia. A diferencia de los trabajos anteriores, en esta ocasión, no sólo se estudian las partes del genoma codificantes de proteínas, también las no codificantes, y ese “es un avance importante”, señala Serena Nik-Zainal, coordinadora de ambas publicaciones. El hecho de no haberlo examinado hasta el momento “dejaba muchas cuestiones sin resolver”, agrega la investigadora.
En la secuenciación genética de los 560 participantes, se identificaron las mutaciones en 93 genes que están implicados en la génesis de la enfermedad y el crecimiento de los tumores, asociados con la reparación del ADN defectuoso y la función de los genes BRCA1 o BRCA2. “Los perfiles genómicos de cada paciente, a pesar de portar el gen BRCA1 y BRCA2, se presentaban muy diferentes entre sí, por lo que lo ideal sería alcanzar un tratamiento preciso e individual adecuado a cada perfil”, señalan los autores.
En el segundo artículo, Nik-Zainal y su equipo utilizaron los mismos 560 genomas del cáncer de mama para demostrar que los distintos tipos de firmas mutacionales encontradas se asociaban con el momento en el que se replican partes del genoma. En conjunto, ambos trabajos ponen de relieve un mapa más actualizado de las alteraciones genéticas implicadas en el cáncer de mama.
Como expone César Rodríguez, oncólogo médico del Hospital Clínico de Salamanca y miembro de la junta directiva de la Sociedad Española de Oncología Médica (SEOM), al comentar este trabajo, “este análisis de genomas complejos, perfiles de mutaciones y subtipos moleculares confirma que las poblaciones de cáncer de mama son incluso más heterogéneas de lo que pensábamos, y probablemente sea lo que vayamos viendo en el resto de tumores sólidos”.
Según Nik-Zainal, “en un futuro nos gustaría ser capaces de perfilar los genomas del cáncer individuales, de manera que podamos identificar el tratamiento con más posibilidades de tener éxito en un hombre o una mujer diagnosticada con cáncer de mama. Este avance nos acerca más a la medicina personalizada, para actuar exactamente donde se producen las mutaciones en los genomas de este tipo de cáncer. Es muy importante”.
Avance hacia terapias más eficaces
Este descubrimiento aporta más causas de estos tumores y proporciona evidencia de que los genomas del cáncer de mama son muy individuales. Como ilustra Serena Nik-Zainal, autora principal de este ambicioso trabajo, “el genoma del cáncer de cada persona es un relato histórico completo de los cambios genéticos que han adquirido a lo largo de la vida”.
Desde el óvulo fecundado y en el transcurso de la edad adulta, el ADN de las células de un individuo van acumulando los sucesivos cambios genéticos. Esto se debe a que “el ADN humano resulta constantemente dañado por factores como el ambiente o, simplemente, por el desgaste de la célula. Estas mutaciones forman patrones que podemos detectar y nos dan pistas sobre las causas del cáncer”.
En esta investigación, aparte de identificar muchas mutaciones diferentes en subgrupos de cáncer de mama, se observa que no todas esas alteraciones tienen una importancia del mismo valor. Las denominadas ‘driver’ son las que proporcionan al tumor una ventaja proliferativa y son esas contra las que hay que actuar. Por ejemplo, el tratamiento ‘personalizado’ que se realiza hoy en la práctica clínica tiene que ver con los subgrupos de cáncer de mama her2 positivo, con terapias dirigidas antiher2. Sin embargo, señala Rodríguez, “estamos viendo que no todos los casos responden igual. Es porque algunos expresan alteraciones moleculares que los hacen diferentes”.
En palabras del director del Wellcome Trust Sanger Institute, Mike Stratton, “todos los cánceres se deben a mutaciones que ocurren en el ADN de nuestras células durante el curso de nuestras vidas. Encontrar estas mutaciones es crucial para entender las causas del cáncer y para desarrollar mejores terapias. Este gran estudio, que examina con gran detalle los muchos miles de mutaciones presentes en cada uno de los genomas de 560 casos, nos acerca a una descripción completa de los cambios en el ADN del cáncer de mama y, por lo tanto, a una comprensión global de las causas de la enfermedad y las posibilidades de nuevos tratamientos”.
Como apunta el especialista español, “este trabajo sirve para que en el futuro, cada cáncer de mama, una vez secuenciado, podamos elaborar un mapa de las alteraciones genéticas, identificando cuáles de ellas son las verdaderamente responsables del tumor y que realmente utilicemos cócteles de fármacos que bloqueen específicamente esos puntos clave en el crecimiento y la proliferación del tumor. Esto que ya estamos viendo en tumores muy concretos, probablemente será el tratamiento del futuro, una medicina personalizada de verdad. La actual es grupal, para pacientes que se parecen”.
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باور این 10 افسانههای
مربوط به لینک سازی خارجی شما را از رشد
بازمیدارد.
به این صورت که بعد از عقد یک قرارداد رسمی که جزئیات پروژه به
صورت دقیق در آن ذکر شده،
کار خود را آغاز میکنند. معمولا کارشناسان سئو
به صورت پروژهای و قراردادی، با کارفرمایان خود همکاری میکنند.
پس حتما به کیفیت لینک های که
به سایتتان داده می شود توجه ویژه داشته
باشید. رپورتاژ، یک مقاله تبلیغاتی است که در آن، به صفحه
یا صفحاتی از یک سایت دیگر لینک داده میشود.
این افراد با خرید هزاران بک لینک بیکیفیت و
پر کردن صفحات سایت با کلمات کلیدی، سعی در رتبه گرفتن درنتایج جستجو داشتند.
با بهینهسازی سئو، میتوان از مزایای
پشتیبانی سئو، بهبود رتبه وب سایت در نتایج جستجو، افزایش ترافیک وبسایت، جذب مخاطبان هدف، افزایش اعتبار و اعتماد، بهبود تجربه کاربری، بازدهی بالا در مقایسه با
تبلیغات پرداختی و رقابتپذیری بیشتر، بهره مند شد.
بک لینک های معتبر و باکیفیت که از سایت های مورد اعتماد خریداری می شوند، به
شما کمک می کنند تا در موتورهای جستجو رتبه بالاتری کسب کنید و محتوایتان
را به مخاطبان هدفتان نشان دهید.
لینک سازی داخلی، به ایجاد لینک در صفحات سایت به صفحات دیگری در همان سایت گفته میشود.این کار، به عنوان یکی از مهمترین
فاکتورهای سئو داخلی شناخته میشود.
همانطور که در وبسایت exposureninja نیز به آن اشاره شده است لینک سازی تنها بخشی از سئو خارجی را شامل میشود؛
البته تاثیر آن در رشد و افزایش ورودیهای
سایت نیز قابل توجه است.
بکلینک دو نوع دارد که شامل بکلینک داخلی است که داخل سایت قرار دارد و از
صفحهای در وبسایت خودتان، به صفحهای دیگر لینک میدهید
و بکلینک خارجی که از یک سایت دیگر به سایت شما لینک
داده بشود. لینک سازی خارجی، بخشی از سئو خارجی است که شامل
فرآیندهای خرید یا ثبت دستی لینک در سایتهای مختلف میشود.
در دوره آموزش لینک سازی خارجی، مهمترین مباحث و نکاتی که برای ساخت
یک بک لینک باکیفیت باید لحاظ شود را
فرا میگیرید. این دوره، بخشی
از دوره “دوره جامع آموزش سئو ۲۰۲۳” دانشجویار است که به صورت جداگانه
قرار داده شده است. پس یک برنامه زمانبندی
مناسب، دقیق و اصولی را برای
لینک سازی و رپورتاژهای خود طراحی نمایید که در آن روزهای مختلفی را
برای درج بک لینک قرار دادهاید و بر اساس
آن پیش بروید. اگر بتوانید به صورت اصولی و طبیعی این کار را انجام
دهید، اعتبار زیادی دریافت میکنید و
به مرور، رتبههای بالاتری در نتایج جستجو دریافت میکنید؛ اما اگر به صورت مصنوعی
و غیراصولی این کار را انجام دهید، شاهد اثرات منفی و گاها پنالتی شدن سایت خواهید بود.
استراتژی در لینک سازی به معنی
آن است که میزان لینک هایی که از سایت ها دریافت میکنید
یا به سایر سایت ها میدهید باید کاملا طبیعی
بوده، بیش از حد یا کم نباشد، هدفمند باشند و با توجه به کلمات کلیدی
و مطابق با برنامه باشند.
اگر بخواهیم بکلینک را به زبانی شیوا توصیف
کنیم باید بگوییم زمانیکه سایتی
به سایت دیگری لینک میدهد، در حقیقت یک
بکلینک ایجاد میکند. لینکسازی
داخلی کمک میکند تا محتوای مربوطه در
سراسر سایت نشان داده شود و به کاربران اجازه میدهد به شکل دقیقتری سایت شما را
مشاهده کنند. لینک داخلی، به لینکی گفته
میشود که از صفحهای به صفحه دیگری در یک سایت داده شود.
بنابراین اگر میزان لینک شما در صفحه محتوا های
شما کمتر از ان چیزی است که تصور می کردید ، احتمالا محتوای بهتری ارائه نکرده اید.
با توجه به تعاریفی که در اینجا ارائه شد، احتمالا با خود فکر میکنید که تمرکز اصلی
سئو خارجی، تنها روی لینک سازی خارجی و گرفتن بک لینک است؛ در صورتی که اینطور نیست!
Th is data wаs g enerated wi tһ GSA Conte nt Ꮐenerator DEMO.
در دوره آموزش لینک سازی خارجی، چه مباحثی را
یاد میگیریم؟ دوره آموزش لینک سازی خارجی در SEO، دورهای است که به صورت تخصصی به سئو خارجی
سایت و لینک سازی (Link Building)
میپردازد. این سایت ها برای لینکدادن به وبسایت
اصلی مورد استفاده قرار میگیرند و در
نتیجه رتبه بندی آن ها را در صفحات نتایج موتورهای جستجو (SERP) افزایش می دهند.
به این دلیل کهوقتی صبح ایمیل
را ارسال میکنید ایمیل شما با حدود ۹۳ ایمیل دیگر
در اینباکس قرار میگیرد. سایت های معتبر فروش بک لینک،
بخشی را به عنوان نمونه کار در سایت شان قرار
داده و نتیجه کارشان را آنجا به کاربران نمایش میدهند.
گوگل با استفاده از لینک های داده شده
به یک صفحه به میزان اهمیت آن صفحه پی می برد، با استفاده از لینک سازی داخلی و خارجی می توانید
به بهینه سازی سایت برای موتورهای جستجو کمک کنید.
بنابراین افراد پس از طراحی وب سایت برای کسب و کار خود لازم است آن را برای موتورهای
جست و جو بهینه سازی نموده و از روش های سئو و تبلیغات استقاده نمایند.
پس از انتخاب آن مطلب به انتهای صفحه قسمت
نظرات رفته و آدرس سایت همراه با کلمهکلیدی و متن مورد نظر را در
آن نوشته و دکمه ارسال را بزنید تا مطلب ارسال
شود.
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بهترین راه درمان سردرد از سفارش
لینک سازی
با توجه به اینکه هر دو روش لینک سازیاز اهمیت
فراوان برای سئو سایتها برخوردارند، بهتر است که الگوریتمی در نظر گرفته شود کهبر چنین تعادلی
تأکید دارد. اگر میخواهید هر دو پلن رپوتاژ ویژه رایاطرح را یکجا داشته باشید میتوانید در پلن 3 با قیمتی بی
نظیر این سرویسها را یکجا سفارش دهید.
پس اگر مشتاق هستید در مورد بک لینکهای با ارزش و نحوه ساخت آنها اطلاعات بیشتری کسب کنید پس حتماً
مطالعه این مطلب را از دست ندهید.
همیشه خوب است که با آنها آزمایش کنید
، اگر قبلاً این کار را نکرده اید.
از همین رو اولین کار و شاید مهم ترین کاری که باید انجام دهید این است
که مطالب خوب منتشر کنید تا کاربران را وادار به انتشار مطالب کنید.
من خودمقطعا این موضوع رو قبول دارم که هر گونه
اقدام مصنوعی برای رشد سئو وبسایتت و یجورایی بهتر بگم برای جلب اعتماد گوگل کار به شدت اشتباهیه.Data wаs creat ed by GSA Ϲontent Generator DEMO.
لطفا توضیحات روبه دقت بخوانید.
در فهرست عنوان و یا نشانکی که می خواهید به آن پیوند دهید انتخاب کنید.
برای اینکه بتوانید اعتماد گوگل را به خود جلب کنید
، بک لینک و پیوند ها یکی از مواردی است که باید به خوبی در آن عمل کنید و موارد دیگر نیز وجود دارد
که باید حتما به ان ها هم توجه داشته باشید.
نوع خاصی از ساخت لینک می باشد که از فروم هایا همان
تالارهای گفتگو به عنوان پلتفرم
اصلی استفاده می کند. مرحله سوم : با استفاده از روش
هایی مثل ارسال پیام به آنها، از
آنها دعوت کنید که از اینفوگرافیک شما دیدن کنند.
بک لینکها درست مثل لینکهای داخلی سایت هستند با این تفاوت که
مقصد آنها به سایت دیگری است نه خود سایت شما.
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